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Ethics statement The animal study was approved by the Institutional Animal Care and Use Committee at Cairo University, Cairo, Egypt (Vet CU13102024983)

For Dihexa to progress in Alzheimer's research, several conditions would need to be met: Earlier intervention: Testing in cognitively normal individuals at high risk, or mild cognitive impairment, rather than established dementia Bioavailability optimization: Development of oral formulations with superior brain penetration, or better-tolerated intravenous regimens Combination approaches: Testing Dihexa alongside amyloid-targeting drugs or tau-focused therapeutics Mechanism refinement: Understanding which aspects of HGF signalling are beneficial versus which drive cancer risk concerns Patient stratification: Identifying subgroups (by genetics, biomarker status, disease stage) most likely to respond Dose optimization: The LIFT-AD trial used specific doses

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212 It also promotes Bcl-2 nuclear translocation and phosphorylation, enhancing apoptosis in estrogen receptor-positive breast cancers